Eleonora F Spinazzi, MD
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Overview
Dr. Eleonora Francesca Spinazzi is a fellowship-trained neurosurgeon specializing in cerebrovascular and endovascular neurosurgery. She delivers expert, evidence-based care for patients with stroke, brain aneurysms, arteriovenous malformations (AVMs), and other complex neurovascular conditions. Her approach blends cutting-edge, minimally invasive techniques with personalized, compassionate care tailored to each patient's goals.
At Columbia University Irving Medical Center, Dr. Spinazzi provides advanced microsurgical and endovascular treatments for both emergent and elective neurovascular disorders. She is committed to offering the highest level of care across the full spectrum of cerebrovascular disease.
Dr. Spinazzi earned her medical degree from Rutgers New Jersey Medical School and completed her neurosurgery residency at NewYork-Presbyterian/Columbia. She then pursued a CAST-accredited fellowship in endovascular neurosurgery at the renowned Barrow Neurological Institute in Phoenix, Arizona -- one of the top training programs in the field.
In addition to her clinical practice, Dr. Spinazzi is a dedicated physician-scientist. Her research spans stroke care and neuromodulation, with a focus on developing new ways to restore brain and nerve function in patients whose conditions do not respond to conventional therapies. She has published in leading journals and textbooks, including The Lancet Oncology, Stroke, and Genome Medicine.
Areas of Expertise / Conditions Treated
- Cerebral Vascular Disease
- Cerebral Vascular Malformation
Academic Appointments
- Assistant Professor of Neurological Surgery at CUMC
Hospital Affiliations
- NewYork-Presbyterian / Columbia University Irving Medical Center
Languages
- English
- Italian
- Spanish
Gender
- Female
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Location(s)
Insurance Accepted
Aetna
- Aetna Signature Administrators
- EPO
- HMO
- Medicare Managed Care
- NY Signature
- POS
- PPO
- Student Health
Affinity Health Plan
- Essential Plan
- Medicaid Managed Care
Amida Care
- Special Needs
Cigna
- EPO
- Great West (National)
- HMO
- Medicare Managed Care
- POS
- PPO
Emblem/GHI
- Medicare Managed Care
- PPO
Emblem/HIP
- ConnectiCare
- EPO
- Essential Plan
- HMO
- Medicaid Managed Care
- Medicare Managed Care
- POS
- PPO
- Select Care (Exchange)
- Vytra
Empire Blue Cross/Blue Shield
- EPO
- HMO
- Medicare Managed Care
- PPO
Empire Blue Cross Blue Shield HealthPlus
- Child/Family Health Plus
- Essential Plan
- Medicaid Managed Care
Fidelis Care
- Child/Family Health Plus
- Essential Plan
- Medicaid Managed Care
- Medicare Managed Care
Healthfirst
- Child/Family Health Plus
- Leaf (Exchange)
- Medicaid Managed Care
- Medicare Managed Care
Horizon Blue Cross Blue Shield
- EPO - New Jersey Services
- HMO - New Jersey Services
- POS - New Jersey Services
- PPO - New Jersey Services
Local 1199
- NYP Employee Plan
MagnaCare (National)
- MagnaCare
Medicare
- Traditional Medicare
Multiplan
- Multiplan
MVP Health Care
- Child/Family Health Plus
- Essential Plan
- HMO
- Medicaid Managed Care
RiverSpring
- Special Needs
UnitedHealthcare
- Compass (Exchange)
- Empire Plan
- HMO
- Medicaid (Community Plan)
- Medicare Managed Care
- Oxford Freedom
- Oxford HMO
- Oxford Liberty
- POS
- PPO
VNSNY CHOICE
- Medicare Managed Care
- SelectHealth
- Special Needs
WellCare
- Medicaid Managed Care
- Medicare Managed Care
World Trade Center Health Plan
- World Trade Center Health Plan
Credentials & Experience
Education & Training
- Rutgers - Robert Wood Johnson Medical School
- Residency: NewYork-Presbyterian / Columbia University Irving Medical Center
- Fellowship: Barrow Neurological Institute
Honors & Awards
2017: Alpha Omega Alpha
2017: Peter W. Carmel M.D. Award in Neurological Surgery
2013: Scholarship, Columbian Foundation
2012: Bronze President’s Volunteer Service Award
Research
Selected Publications
1. Ropri AS, Lam TG, Kalia V, Buchanan HM, Bartosch AMW, Youth EHH, Xiao H, Ross SK, Jain A, Chakrabarty JK, Kang MS, Boyett D, Spinazzi EF, Iodice G, McGovern RA, Honig LS, Brown LM, Miller GW, McKhann GM, Teich AF. Alzheimer's disease CSF biomarkers correlate with early pathology and alterations in neuronal and glial gene expression. Alzheimers Dement. 2024 Oct;20(10):7090-7103. doi: 10.1002/alz.14194. Epub 2024 Aug 27. PMID: 39192661; PMCID: PMC11485399.
2. Jung T, Zeng N, Fabbri JD, Eichler G, Li Z, Zabeh E, Das A, Willeke K, Wingel KE, Dubey A, Huq R, Sharma M, Hu Y, Ramakrishnan G, Tien K, Mantovani P, Parihar A, Yin H, Oswalt D, Misdorp A, Uguz I, Shinn T, Rodriguez GJ, Nealley C, Sanborn S, Gonzales I, Roukes M, Knecht J, Yoshor D, Canoll P, Spinazzi E, Carloni LP, Pesaran B, Patel S, Jacobs J, Youngerman B, Cotton RJ, Tolias A, Shepard KL. Stable, chronic in-vivo recordings from a fully wireless subdural-contained 65,536-electrode brain-computer interface device. bioRxiv [Preprint]. 2025 Mar 9:2024.05.17.594333. doi: 10.1101/2024.05.17.594333. PMID: 38798494; PMCID: PMC11118429.
3. Sperring CP, Savage WM, Argenziano MG, Leifer VP, Alexander J, Echlov N, Spinazzi EF, Connolly ES Jr. No-Reflow Post-Recanalization in Acute Ischemic Stroke: Mechanisms, Measurements, and Molecular Markers. Stroke. 2023 Sep;54(9):2472-2480. doi: 10.1161/STROKEAHA.123.044240. Epub 2023 Aug 3. PMID: 37534511.
4. Spinazzi EF, Argenziano MG, Upadhyayula PS, Banu MA, Neira JA, Higgins DMO, Wu PB, Pereira B, Mahajan A, Humala N, Al-Dalahmah O, Zhao W, Save AV, Gill BJA, Boyett DM, Marie T, Furnari JL, Sudhakar TD, Stopka SA, Regan MS, Catania V, Good L, Zacharoulis S, Behl M, Petridis P, Jambawalikar S, Mintz A, Lignelli A, Agar NYR, Sims PA, Welch MR, Lassman AB, Iwamoto FM, D'Amico RS, Grinband J, Canoll P, Bruce JN. Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial. Lancet Oncol. 2022 Nov;23(11):1409-1418. doi: 10.1016/S1470-2045(22)00599-X. Epub 2022 Oct 13. PMID: 36243020; PMCID: PMC9641975.
5. Huang W, Bartosch AM, Xiao H, Maji S, Youth EHH, Flowers X, Leskinen S, Tomljanovic Z, Iodice G, Boyett D, Spinazzi E, Menon V, McGovern RA, McKhann GM, Teich AF. An immune response characterizes early Alzheimer's disease pathology and subjective cognitive impairment in hydrocephalus biopsies. Nat Commun. 2021 Sep 27;12(1):5659. doi: 10.1038/s41467-021-25902-y. PMID: 34580300; PMCID: PMC8476497.
6. Zhao W, Dovas A, Spinazzi EF, Levitin HM, Banu MA, Upadhyayula P, Sudhakar T, Marie T, Otten ML, Sisti MB, Bruce JN, Canoll P, Sims PA. Deconvolution of cell type-specific drug responses in human tumor tissue with single-cell RNA-seq. Genome Med. 2021 May 11;13(1):82. doi: 10.1186/s13073-021-00894-y. PMID: 33975634; PMCID: PMC8114529.
7. Upadhyayula PS, Higgins DM, Argenziano MG, Spinazzi EF, Wu CC, Canoll P, Bruce JN. The Sledgehammer in Precision Medicine: Dexamethasone and Immunotherapeutic Treatment of Glioma. Cancer Invest. 2022 Jul;40(6):554-566. doi: 10.1080/07357907.2021.1944178. Epub 2022 Mar 24. PMID: 34151678.
8. Englander ZK, Wei HJ, Pouliopoulos AN, Bendau E, Upadhyayula P, Jan CI, Spinazzi EF, Yoh N, Tazhibi M, McQuillan NM, Wang TJC, Bruce JN, Canoll P, Feldstein NA, Zacharoulis S, Konofagou EE, Wu CC. Focused ultrasound mediated blood-brain barrier opening is safe and feasible in a murine pontine glioma model. Sci Rep. 2021 Mar 22;11(1):6521. doi: 10.1038/s41598-021-85180-y. PMID: 33753753; PMCID: PMC7985134.
9. Upadhyayula PS, Spinazzi EF, Argenziano MG, Canoll P, Bruce JN. Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience. Pharmaceutics. 2020 Dec 30;13(1):39. doi: 10.3390/pharmaceutics13010039. PMID: 33396668; PMCID: PMC7823846.
For a complete list of publications, please visit PubMed.gov